Frontispiece: Fast Cysteine Bioconjugation Chemistry
نویسندگان
چکیده
In this contribution, we attempt to define fast cysteine bioconjugation, in contrast the traditional modifying reactions that are kinetically slow. A conjugation reaction can allow facile quantitative labeling of proteins with minimized side and much simplified purification. substantial collection novel have been developed towards end some displaying rates over 103 M−1 s−1. This Concept article discusses design principles mechanisms, rate constants summarized provide valuable reference data for further development highly efficient protein reactions. More information be found by J. Gao F.-J. Chen. (DOI: 10.1002/chem.202201843)
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ژورنال
عنوان ژورنال: Chemistry: A European Journal
سال: 2022
ISSN: ['0947-6539', '1521-3765']
DOI: https://doi.org/10.1002/chem.202286663